Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052246 | FEBS Letters | 2006 | 9 Pages |
Abstract
We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene.
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Authors
Adelino V.M. Canario, Josep Rotllant, Juan Fuentes, Pedro M. Guerreiro, H. Rita Teodósio, Deborah M. Power, Melody S. Clark,