Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052369 | FEBS Letters | 2006 | 4 Pages |
Abstract
Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Takaaki Tomofuji, Tetsuji Azuma, Hiroki Kusano, Toshihiro Sanbe, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Tatsuo Watanabe,