Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052386 | FEBS Letters | 2006 | 6 Pages |
Abstract
The testis-determining gene SRY is not well-conserved among mammals, particularly between mouse and other mammals, both in terms of protein structure and of expression regulation. To evaluate SRY phylogenic conservation in regards to its function, we expressed the goat gene (gSRY) in XX transgenic mouse gonads. Here, we show that gSRY induces testis formation, despite a goat expression profile. Our results demonstrate that sex-reversal can be induced in XX-mice by a non-mouse SRY thus suggesting a conserved molecular mechanism of action of this testis-determining gene across mammalian species.
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Authors
Maëlle Pannetier, Gaëlle Tilly, Ayhan Kocer, Marthe Hudrisier, Lauriane Renault, Nathalie Chesnais, José Costa, Fabienne Le Provost, Daniel Vaiman, Jean-Luc Vilotte, Eric Pailhoux,