Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052387 | FEBS Letters | 2006 | 5 Pages |
Abstract
Tunicamycin is a well-known inhibitor of protein glycosylation and used as an inducer of endoplasmic reticulum (ER) stress. We found that tunicamycin induced expression of cytochrome P450 1A1 in a dose-dependent manner. Like dioxin, the transcriptional induction was associated with dose-dependent activation of the dioxin responsive element (DRE). This effect was independent of inhibition of protein glycosylation or induction of ER stress. Pharmacological and genetic inhibition of the aryl hydrocarbon receptor (AhR) significantly attenuated activation of DRE by tunicamycin. These results elucidated the novel potential of tunicamycin as an activator of the AhR – DRE signaling pathway.
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Authors
Kyohei Horikawa, Naoki Oishi, Jin Nakagawa, Ayumi Kasai, Kunihiro Hayakawa, Nobuhiko Hiramatsu, Yosuke Takano, Makiko Yokouchi, Jian Yao, Masanori Kitamura,