Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052490 | FEBS Letters | 2006 | 6 Pages |
Abstract
A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.
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Authors
Patrícia Oliveira Prada, José Rodrigo Pauli, Eduardo Rochete Ropelle, Henrique Gottardello Zecchin, José Barreto Campello Carvalheira, Lício Augusto Velloso, Mario José Abdalla Saad,