Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052512 | FEBS Letters | 2005 | 5 Pages |
Abstract
We show by mathematical modelling that a two-level protein cascade can act as a band-pass filter for time-limited oscillations. The band-pass filters are then combined into a network of three-level signalling cascades that by filtering the frequency of time-limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations.
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Authors
Marko Marhl, Matjaž Perc, Stefan Schuster,