| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2052515 | FEBS Letters | 2005 | 6 Pages |
Abstract
The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-β1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development.
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Authors
Elena Albè, Elizabeth Escalona, Rama Rajagopal, Joel A. Javier, Jin-Hong Chang, Dimitri T. Azar,