Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052570 | FEBS Letters | 2005 | 5 Pages |
Abstract
Previously, we found that safrole oxide could trigger vascular endothelial cell (VEC) apoptosis. In this study, to investigate its mechanism to induce apoptosis in VECs, the activities of nitric oxide synthetase and phosphatidylcholine specific phospholipase C, the level of reactive oxygen species and the expressions of Fas, integrin β4 and P53 were analyzed. The data showed that safrole oxide induced apoptosis by increasing the expressions of Fas, integrin β4 and P53, and depressing the activity of Ca2+-independent phosphatidylcholine-specific phospholipase C and intracellular reactive oxygen species levels in VECs.
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Authors
Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang,