| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2052587 | FEBS Letters | 2006 | 5 Pages |
Abstract
Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol. In addition, both retinoids stimulated the calcium-dependent binding of AnxA6 to liposomes, accompanied by oligomerization of AnxA6. Up to our knowledge, it is a first report supporting the hypothesis of a direct implication of AnxA6 in vitamin A-dependent tissue mineralization.
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Authors
Marcin Balcerzak, Joanna Bandorowicz-Pikula, Rene Buchet, Slawomir Pikula,