Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052624 | FEBS Letters | 2006 | 6 Pages |
Abstract
RPLKPW is a potent anti-hypertensive peptide designed according to the structure of ovokinin(2–7) (RADHPF). In this study, we generated transgenic rice plants that accumulate the RPLKPW peptide as a fusion protein with the rice storage protein glutelin. The engineered peptide is expressed under the control of endosperm-specific glutelin promoters and specifically accumulates in seeds. Oral administration of either the RPLKPW-glutelin fraction or transgenic rice seeds to spontaneously hypertensive rats (SHRs) significantly reduced systolic blood pressures. These results suggest the possible application of transgenic rice seed as a nutraceutical delivery system and specifically for administration of active peptides in hypertension.
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Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Lijun Yang, Yoshifumi Tada, Masayuki P. Yamamoto, Hui Zhao, Masaaki Yoshikawa, Fumio Takaiwa,