Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052651 | FEBS Letters | 2006 | 5 Pages |
Abstract
Overexpression of forkhead transcription factor FOXC2 in white adipose tissue (WAT) leads to a lean phenotype resistant to diet-induced obesity. This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Here we show that rolipram treatment of adipocytes from FOXC2 transgenic mice did not increase isoproterenol-induced cAMP accumulation to the same extent as in wild type cells. Accordingly, phosphodiesterase-4 (PDE4) activity was reduced by 75% and PDE4A5 protein expression reduced by 30–50% in FOXC2 transgenic WAT compared to wild type. Thus, reduced PDE4 activity in adipocytes from FOXC2 transgenic mice contributes to amplified β-AR induced cAMP responses observed in these cells.
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Authors
Line M. Grønning, George S. Baillie, Anna Cederberg, Martin J. Lynch, Miles D. Houslay, Sven Enerbäck, Kjetil Taskén,