Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052659 | FEBS Letters | 2006 | 4 Pages |
Abstract
We quantitatively measured protective antigen (PA) binding to human cells targeted by anthrax lethal toxin (LT). Affinities were less than 50 nM for all cells, but differentiated cells (macrophages and neutrophils) had significantly increased PA binding and endothelial cells demonstrated the most binding. Combined with the function of such cells, this suggests that PA receptors interact with the extracellular matrix and that differentiation increases the number of PA-specific receptors, which supports previously observed differentiation-induced LT susceptibility. Our results quantifiably confirm that the generality of PA binding will complicate its use as a tumor targeting agent.
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Authors
Alina Deshpande, Rebecca J. Hammon, Claire K. Sanders, Steven W. Graves,