Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052675 | FEBS Letters | 2006 | 8 Pages |
Abstract
As a cell-specific organelle, acrosome (Acr) and its formation are an important event for spermiogenesis. However, the Acr formation is far more complicated than has been proposed. In this study, we have cloned a novel membrane protein Afaf (Acr formation associated factor) that was expressed abundantly in the round spermatids, localized in the inner and outer membrane of forming Acrs, and declined in the maturing Acrs. In the transfected Hela cells, Afaf protein was localized in the plasma membrane, EEA1-positive early endosomes (EEs) and occasionally in the nuclei. Therefore, we propose that EEs and plasma membrane may be also directly involved in the Acr biogenesis.
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Authors
Yin-Chuan Li, Xiao-Qian Hu, Ke-Ying Zhang, Jian Guo, Zhao-Yuan Hu, Shi-Xin Tao, Li-Juan Xiao, Qing-Zhong Wang, Chun-Sheng Han, Yi-Xun Liu,