Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052738 | FEBS Letters | 2006 | 10 Pages |
Abstract
The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses – the cell cycle arrest response – into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.
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Authors
Joan Massagué, Roger R. Gomis,