| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2052808 | FEBS Letters | 2006 | 7 Pages |
Abstract
DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor of dendritic cells and is involved in the initial steps of numerous infectious diseases. Surface plasmon resonance has been used to study the affinity of a glycodendritic polymer with 32 mannoses, to DC-SIGN. This glycodendrimer binds to DC-SIGN surfaces in the submicromolar range. This binding depends on a clustered organization of DC-SIGN mimicking its natural organization as microdomain in the dendritic cells plasma membrane. Moreover, this compound inhibits DC-SIGN binding to the HIV glycoprotein gp120 with an IC50 in the micromolar range and therefore can be considered as a potential antiviral drug.
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Authors
Georges Tabarani, José J. Reina, Christine Ebel, Corinne Vivès, Hugues Lortat-Jacob, Javier Rojo, Franck Fieschi,