Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052810 | FEBS Letters | 2006 | 7 Pages |
Abstract
SARS-associated coronavirus was identified as the etiological agent of severe acute respiratory syndrome and a large virus pool was identified in wild animals. Virus generates drug resistance through fast mutagenesis and escapes antiviral treatment. siRNAs targeting different genes would be an alternative for overcoming drug resistance. Here, we report effective siRNAs targeting structural genes (i.e., spike, envelope, membrane, and nucleocapsid) and their antiviral kinetics. We also showed the synergistic effects of two siRNAs targeting different functional genes at a very low dose. Our findings may pave a way to develop cost effective siRNA agents for antiviral therapy in the future.
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Authors
Ming-Liang He, Bo-jian Zheng, Ying Chen, Kin-Ling Wong, Jian-Dong Huang, Marie C. Lin, Ying Peng, Kwok Y. Yuen, Joseph J.Y. Sung, Hsiang-fu Kung,