Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052817 | FEBS Letters | 2006 | 6 Pages |
Abstract
We investigated the effect of modeled microgravity (MMG) on normal vascular smooth muscle cells (VSMC) and neoplastic human breast cancer cells (MCF-7). In both cell types, MMG induced partial arrest in G2M and increased p14-3-3, HSP70, HSP60 and p21 expression. Cells synchronized by 24 h starvation reentered the normal cycle within 24 h if released in complete medium and exposed to normal gravity, but not if exposed to MMG. Similarly, MMG prevented VSMC and MCF-7 cells from overcoming growth arrest and re-synthesizing DNA. This study shows that cells adjust their metabolic rate in response to MMG.
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Authors
Rita Coinu, Angela Chiaviello, Grazia Galleri, Flavia Franconi, Elvira Crescenzi, Giuseppe Palumbo,