Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052895 | FEBS Letters | 2006 | 6 Pages |
Abstract
Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.
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Agricultural and Biological Sciences
Plant Science
Authors
Hitomi Nakamura, Tadashi Kimura, Shinsuke Koyama, Kazuhide Ogita, Tateki Tsutsui, Koichiro Shimoya, Takeshi Taniguchi, Masayasu Koyama, Yasufumi Kaneda, Yuji Murata,