Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052906 | FEBS Letters | 2006 | 9 Pages |
Abstract
Serum levels of advanced glycation end products (AGEs) are associated with an acute phase reactant, C-reactive proteins (CRP) in diabetic patients. However, whether AGEs could directly stimulate hepatic CRP production remains to be elucidated. We found here that AGEs upregulated CRP mRNA levels in cultured Hep3B cells via Rac-1 activation, which was blocked by pigment epithelium-derived factor (PEDF). Our present study suggests that AGEs are one of the potent inducers of CRP and that PEDF may work as an anti-inflammatory agent against AGEs in the liver.
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Authors
Takafumi Yoshida, Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Tsutomu Imaizumi, Masayoshi Takeuchi, Takato Ueno, Michio Sata,