| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2052942 | FEBS Letters | 2006 | 6 Pages |
Abstract
Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms.
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Authors
Natsue Yoshimura, Daisuke Horiuchi, Masao Shibata, Minoru Saitoe, Mei-ling Qi, Hitoshi Okazawa,