Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052975 | FEBS Letters | 2006 | 4 Pages |
Abstract
It was recently shown that there is a predominance of phase 1 introns near the cleavage site of signal peptides encoded by human genes [Tordai, H. and Patthy, L. (2004) Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides. FEBS Lett. 575, 109–111]. It was suggested that this biased distribution was due to intron insertion at AG∣G proto-splice sites. However, we found that there is no disproportional excess of AG∣G that would support insertion at proto-splice sites. In fact, all nG∣G sites are enriched in the vicinity of the cleavage site. Additional analyses support an alternative scenario in which exon-shuffling is largely responsible for such excess of phase 1 introns.
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Authors
Maria Dulcetti Vibranovski, Noboru Jo Sakabe, Sandro José de Souza,