Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052998 | FEBS Letters | 2006 | 7 Pages |
Abstract
The FOXM1 forkhead proteins, originally identified as M-phase phosphoproteins, are proliferation-associated transcriptional regulators involved in cell cycle progression, genetic stability and tumorigenesis. Here we demonstrate that Cyclin-dependent kinases regulate the transcriptional activity of FOXM1c. This is independent of an N-terminal negative regulatory domain and of the forkhead DNA binding domain. Instead we mapped the responsive sites in the transactivation domain. A combination of three phosphorylation sites mediates the Cyclin E and Cyclin A/CDK2 effects. Our findings provide evidence for a novel Cyclin E/CDK2 substrate that functions in cell cycle control.
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Authors
Juliane M. Lüscher-Firzlaff, Richard Lilischkis, Bernhard Lüscher,