Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053043 | FEBS Letters | 2006 | 8 Pages |
Abstract
Extracellular ATP is known to affect the maturation of monocyte-derived dendritic cells mainly by regulation of cytokines and costimulatory molecules. The present study describes the inhibition of MCP-1 (CCL2) and MIP-1α (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Our pharmacological data support the involvement of P2Y11 and P2Y1 purinergic receptors in the downregulation of these major monocyte recruiters. Migration assays have demonstrated that supernatants of dendritic cells treated with adenine nucleotides or anti-MCP-1/MIP-1α blocking antibodies display a strongly reduced capacity to attract monocytes and immature dendritic cells.
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Authors
Michael Horckmans, Brice Marcet, Frédéric Marteau, Frédéric Bulté, Arielle Maho, Marc Parmentier, Jean-Marie Boeynaems, Didier Communi,