Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053102 | FEBS Letters | 2005 | 7 Pages |
Abstract
The hypoxia responsive region (HRR) of the VEGF promoter plays a key role in regulating VEGF expression. We found that the cold shock domain (Y-box) repressor proteins, dbpA and dbpB/YB-1, bind distinct strands of the human VEGF HRR. We find both dbpA and dbpB are phosphorylated by ERK2 and GSK3β in vitro, and the binding of dbpB to single-strand VEGF HRR DNA is regulated by this phosphorylation. These findings suggest the ERK/MAPK and PI3K pathways may regulate VEGF expression in part through regulating the action of these repressor proteins.
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Authors
Leeanne S. Coles, Lidia Lambrusco, Julie Burrows, Julie Hunter, Peter Diamond, Andrew G. Bert, Mathew A. Vadas, Gregory J. Goodall,