| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2053131 | FEBS Letters | 2005 | 5 Pages |
Abstract
Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose–response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior.
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Authors
Karina R. Guidugli, Adriana M. Nascimento, Gro V. Amdam, Angel R. Barchuk, Stig Omholt, Zilá L.P. Simões, Klaus Hartfelder,