Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053144 | FEBS Letters | 2005 | 5 Pages |
Abstract
The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (Ka) of (1.8 ± 0.3) × 106 M−1. Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 °C, for the conditions of our study.
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Authors
Feifei Xing, Guangtao Song, Jinsong Ren, Jonathan B. Chaires, Xiaogang Qu,