Article ID Journal Published Year Pages File Type
2053144 FEBS Letters 2005 5 Pages PDF
Abstract

The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (Ka) of (1.8 ± 0.3) × 106 M−1. Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 °C, for the conditions of our study.

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