Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053153 | FEBS Letters | 2005 | 6 Pages |
Abstract
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Frank J. Gunn-Moore, Gavin I. Welsh, Lissa R. Herron, Frances Brannigan, Kanamarlapudi Venkateswarlu, Stewart Gillespie, Margaret Brandwein-Gensler, Rashna Madan, Jeremy M. Tavaré, Peter J. Brophy, Michael B. Prystowsky, Simon Guild,