Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053155 | FEBS Letters | 2005 | 5 Pages |
Abstract
Angiotensin II (Ang II) induces a prominent and sustained nitration and activation of ERK1/2 in rat vascular smooth muscle cells, both mediated via AT1 receptor. Nitration and activation was also shown for recombinant non-activated extracellular signal-regulated kinase (ERK) and MEK. Nitration and phosphorylation of ERK1/2 by Ang II was significantly inhibited by NAD(P)H inhibitors and scavengers of oxygen and nitrogen reactive species and completely blocked by a selective inducible nitric-oxide synthase inhibitor. MEK inhibitor U0126 did not affect ERK nitration but completely blocked activation. These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway.
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Authors
Elena Pinzar, Tianyi Wang, Maria R. Garrido, Wei Xu, Patrick Levy, Serge P. Bottari,