Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053219 | FEBS Letters | 2005 | 8 Pages |
Abstract
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction.
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Authors
James C.B. Li, Davy C.W. Lee, Benny K.W. Cheung, Allan S.Y. Lau,