Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053236 | FEBS Letters | 2005 | 7 Pages |
Abstract
In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance.
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Authors
Raphael R. Prattali, Guilherme C. Barreiro, Caio T. Caliseo, Felipe Y. Fugiwara, Mirian Ueno, PatrÃcia O. Prada, Licio A. Velloso, Mario J.A. Saad, José B.C. Carvalheira,