| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2053240 | FEBS Letters | 2005 | 8 Pages |
Abstract
A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.
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Authors
Naomi Siew, Harpreet Kaur Saini, Daniel Fischer,