Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053254 | FEBS Letters | 2005 | 6 Pages |
Abstract
Sterol-enriched lipid rafts have been involved in Drosophila membrane signalling such as Hedgehog targeting and glutamate receptor ligand-affinity regulation. Here, we show that the voltage-dependent K+ currents expressed by the intrinsic neurons of the Mushroom bodies are upward-modulated by compounds that remove sterols from the plasma membrane. Modulation seems to rely on a fast-exchanging sterol-pool, which more strongly affects the slowly inactivating current. Our results provide the first evidence that sterols influence the operation of voltage-gated ion channels in Drosophila neurons and strengthen the importance of lipid rafts in this biological model.
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Authors
Gabriel Gasque, Pedro Labarca, Alberto Darszon,