Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053267 | FEBS Letters | 2005 | 6 Pages |
Abstract
Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as predicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC-content, G3 follows a biphasic relationship, while C3 increases with CAI. In AT-rich bacteria, correlation of CAI is negative with G3, but non-specific with C3. Correlations of CAI with residues encoded by G-starting codons are positive, while with those by C-starting codons are usually negative/random. Average Size/Complexity Score and aromaticity of gene-products decrease with CAI, confirming general validity of cost-minimization principle in free-living eubacteria. Alcoholicity of bacterial gene-products usually decreases with expressivity.
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Authors
Sabyasachi Das, Subhagata Ghosh, Archana Pan, Chitra Dutta,