Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2053405 | FEBS Letters | 2005 | 5 Pages |
Abstract
In whole-cell recordings on primary cultures of human hepatocytes, we observe the hypertonic activation of a novel type of cation channel with a permeability ratio for Na+:Li+:K+:Cs+:NMDG+ of 1:1.2:1.3:1.2:0.6. With a PCa/PNa of 0.7 the channel is also clearly permeable to Ca++. Most likely, the channel is Cl− impermeable but its activity critically depends on the extracellular Cl− concentration (with the half maximal effect at 88 mmol/l). With a 64% inhibition by amiloride and a complete block by flufenamate and Gd3+ (at 100 μmol/l each), the channel may represent a molecular link between the amiloride-sensitive and insensitive channels reported so far.
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Authors
Tongju Li, Frank ter Veld, Hartwig R. Nürnberger, Frank Wehner,