| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2062431 | Reproductive Biology | 2014 | 5 Pages |
Abstract
The adverse effects of the anti-cancer agent cyclophosphamide (CTX) on follicular growth and ovarian angiogenesis were investigated in mice. CTX treatment irreversibly induced a loss of follicles through apoptosis and decreased microvascularization of the corpora lutea and follicles in a dose-dependent manner. Our findings demonstrated that CTX adversely affected the ovaries indicating the need to support an awareness of fertility preservation before chemotherapy is initiated.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
Kenji Ezoe, Nana Murata, Akiko Yabuuchi, Takashi Okuno, Tamotsu Kobayashi, Osamu Kato, Keiichi Kato,