Association of PvuII polymorphism in ESR1 gene with impaired ovarian reserve in patients from Ukraine

The association of ESR1 PvuII polymorphism (rs2334693) with impaired ovarian reserve was studied by genotyping this polymorphism using PCR-RFLP in patients and two control groups from Ukraine. Statistically significant differences in the prevalence of p-allele frequency (−397T) was seen in the group of patients with impaired ovarian reserve (0.597) compared to control groups I under 35 years (0.480) and II over 35 years (0.453), both p < 0.05. The data suggest that PvuII polymorphism of ESR1 is associated with diminished ovarian reserve.