Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2062882 | Reproductive Biology | 2009 | 6 Pages |
Abstract
SUMMARYThe influence of prolactin (PRL) and corticosterone on insulin binding to purified rat Leydig cells was assessed in vitro. The lowest dose of PRL (50 ng/ml) increased (p<0.05) and the remaining PRL concentrations (100, 150, 200, 250 ng/ml) decreased (p<0.05) the insulin binding to Leydig cells. All doses of corticosterone (150, 200, 250, 300 ng/ml) except the lowest one (100 ng/ml) decreased the insulin binding. In conclusion, hyperprolactinemia or excess glucocorticoids associated with an impairment of testicular steroidogenesis may be mediated by a defective insulin binding to Leydig cells.
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Authors
Muthukumar Karthikeyan, Jagadeesan Arunakaran, Karundevi Balasubramanian,