Hydrogenation of bis-α,β-unsaturated enones mediated by filamentous fungi

In this study was used two strains of marine-derived fungi (Penicillium citrinum CBMA1186 and Trichoderma sp. CBMAI 932) and two strains of terrestrial fungi (Aspergillus sp. FPZSP 146 and Aspergillus sp. FPZSP 152) to biotransformation bis-α,β-unsaturated ketones 1-2 to their corresponding 1,5-diphenylpentan-3-one (1a), (E)-1,5-diphenylpent-1-en-3-one (1b), 1,5-diphenylpentan-3-ol (1c), (E)-1,5-diphenylpent-1-en-3-ol (1d), 1,5-bis(4-methoxyphenyl)pentan-3-one (2a), (E)-1,5-bis(4-methoxyphenyl)pent-1-en-3-one (2b) and 1,5-bis(4-methoxyphenyl)pentan-3-ol (2c). The products were obtained in up to 84% conversion employing cultural broth and whole mycelia of mentioned fungi.