Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2094319 | Stem Cell Research | 2016 | 4 Pages |
Abstract
Human iPSC line PG64SV.2 was generated from fibroblasts of a patient with a defect of intergenomic communication. This patient harbored a homozygous mutation (c.2243G>C; p.Trp748Ser) in the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma gene (POLG). Reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non integrative methodology that involves the use of Sendai virus.
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Authors
Francisco Zurita, Teresa Galera, Cristina González-Páramos, Ana Moreno-Izquierdo, Peter Schneiderat, Mario F. Fraga, Agustin F. Fernández, Rafael Garesse, M. Esther Gallardo,