Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2094469 | Stem Cell Research | 2014 | 11 Pages |
Abstract
The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.
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Authors
Zhiqiang Lin, William T. Pu,