Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2168392 | Cryobiology | 2015 | 5 Pages |
Abstract
The aim of this study is to determine the link between oocyte cryopreservation and endoplasmic reticulum (ER) stress; whether ER stress inhibition improves the efficiency of oocyte vitrification is also explored. Oocytes from mice were exposure to tauroursodeoxycholic acid (TUDCA, an ER stress inhibitor) or TM (tunicamycin, an ER stress inducer) with or without vitrification. The expressions of X-box binding protein-1 (XBP-1) protein and caspase-12 protein, viability of vitrified-warmed oocytes, and their subsequent embryo competence were measured. The levels of XBP-1 protein and caspase-12 protein expressio
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Authors
Nan Zhao, Xue-Jun Liu, Jun-Tao Li, Ling Zhang, Yang Fu, Ya-Jie Zhang, Ru-Xin Chen, Xiao-Qing Wei, Rui Wang, Yu Wang, Jian-Min Zhang,