Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2179188 | European Journal of Cell Biology | 2006 | 8 Pages |
Abstract
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.
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Authors
F. Donelson Smith, John D. Scott,