Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2204021 | Tissue and Cell | 2010 | 5 Pages |
Abstract
We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p < 0.05), with Par-4 and hTERT expression being negatively correlated (p < 0.05, r = −0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.
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Authors
Jian-Fei Sheng, Wei Chen, Yan Yu, Jun Liu, Ze-Zhang Tao,