Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2394810 | Journal of Equine Veterinary Science | 2015 | 6 Pages |
Abstract
Intrauterine infusion of a commercial preparation of enrofloxacin has been shown to produce severe inflammation and irreversible deterioration of endometrial biopsy scores in mares. The aim of the present work was to evaluate the effect of intrauterine infusion of a water-based enrofloxacin suspension on mare reproductive tracts. Eight systemically healthy mares were used in the experiment. Each mare underwent a complete reproductive evaluation (ultrasonography, vaginal examination, endometrial cytology, endometrial culture, and endometrial biopsy) before treatment. Each mare received an infusion of 50Â mL of a 2.5% water-based suspension of enrofloxacin daily for 3Â days. To evaluate the acute effect of treatment, mares were examined daily by transrectal ultrasonography and vaginoscopy during the treatment and an endometrial biopsy was obtained 24Â hours after the final infusion. To evaluate the chronic effect of treatment, a complete reproductive evaluation was performed on mares 21Â days after initiation of treatment. Results of clinical evaluation showed a significant increase in intrauterine fluid accumulation during the treatment. A nonsignificant increase in endometrial biopsy grade was observed after the 3Â days of treatment. There was no long-lasting effect of the infusion on clinical evaluation or endometrial histology. Endometrial concentrations of enrofloxacin and its metabolite ciprofloxacin were highly variable among mares yet were above the minimum inhibitory concentration in four of eight treated mares. We conclude that intrauterine infusion of a water-based enrofloxacin solution produced only a transient inflammatory response and may be useful for the treatment of bacterial endometritis sensitive to enrofloxacin without the deleterious effects seen with the administration of the commercial preparation.
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Authors
Maria R. Schnobrich, Lisa K. Pearson, Bart K. Barber, Etta Bradecamp, Ahmed Tibary,