| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2398145 | Journal of Feline Medicine & Surgery | 2009 | 4 Pages |
Abstract
The presence of HER-2/neu (c-erbB-2) oncoprotein, oestrogen-α receptor (ER), and progesterone receptor (PR) in hyperplastic endometrial polyps (EPs) of two cats with cystic endometrial hyperplasia-pyometra (CEH-P) complex was investigated. Immunohistochemistry assay for ER, PR and c-erbB-2 oncoprotein in the glandular and stromal tissue of the EPs was performed. ER and c-erbB-2 immunoreactivity was observed in the glandular epithelium of the EPs whereas PR immunoreactivity was detected only in the stromal fibroblasts. The c-erbB-2 oncoprotein may play a role with the ER in the pathogenesis of the hyperplastic EPs, although the role of this oncoprotein in the pathogenesis of EPs has yet to be determined.
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Authors
Deniz DVM, PhD, Deniz DVM, PhD, Musa Ozgur DVM, PhD, Yavuz DVM, PhD, Ahmet DVM, PhD,