Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review

•First case treated successfully with combination antifungals and interferon-gamma.•Difficulty in diagnosing IPA in intensive care patients is discussed.•Case demonstrates antifungal drug interactions with other medications.•We show repeat imaging and sampling is useful to assess response to antifungals.•Evidence for using long-term antifungal treatment is discussed.

The use of extracorporeal membrane oxygenation (ECMO) for reversible pulmonary failure in critically ill patients has increased over the last few decades. Nosocomial infections are a major complication of ECMO and fungi have been found to be a common cause. Herein, we describe a case of invasive pulmonary aspergillosis following ECMO, which was successfully treated with combination antifungal therapy and interferon-gamma.