Article ID Journal Published Year Pages File Type
2425610 Aquaculture 2007 6 Pages PDF
Abstract

The plasmin(ogen) binding property of pathogenic bacteria is suggested to be one of the characteristics that may contribute to tissue invasion. Recently, the presence of a surface-localized α-enolase that binds both plasmin and plasminogen has been reported from Streptococcus pyogenes and from S. pneumoniae. To investigate whether α-enolase of S. iniae has similar characteristics to that of the above streptococci, in the present study, we have produced α-enolase as a recombinant protein from a fish pathogenic S. iniae strain, and demonstrated for the first time its plasmin(ogen)-binding ability and cell wall-association using immunoblot method. These results suggest that α-enolase of S. iniae may be responsible in part for the ability of S. iniae to cross tissue barriers through plasminogen activation.

Related Topics
Life Sciences Agricultural and Biological Sciences Aquatic Science
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