Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2427016 | Behavioural Processes | 2012 | 9 Pages |
Abstract
⺠The failure in translating the apparent successes of preclinical neuroscience constitutes a serious problem for drug discovery on multiple fronts. ⺠Factors that contribute to this limitation can be categorized under three headings: (1) sociological factors: conflict of interest, social pressures; (2) statistical factors: lack of experimental and statistical design prior to experimentation and replication, susceptibility to false positives; (3) translational factors: weak construct and etiological validity, superficial study of behavior. ⺠These issues are identified and evaluated within the context of drug discovery. Possible solutions are offered.
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Authors
Dani Brunner, Fuat Balcı, Elliot A. Ludvig,