| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2437875 | Journal of Comparative Pathology | 2013 | 5 Pages |
Abstract
SummaryTwo Kirk's dik-diks suffered from chronic, unilateral, therapy-resistant enlargement of the preorbital gland. Computed tomographic imaging revealed a homogenous preorbital mass destroying the adjacent maxillary bone in one animal. Squamous cell carcinoma was diagnosed microscopically in both cases. Immunohistochemically, the neoplastic cells uniformly expressed cytokeratin (CK) 5/6 and CK14. Additionally, tumour cells were strongly labelled for p53 suggesting a possible role of this tumour suppressor gene in tumorigenesis. Chronic obstruction of the preorbital gland due to excessive accumulation of secretory products is considered as a likely cause of glandular and periglandular inflammation with subsequent malignant transformation.
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Authors
J. Junginger, M. Kummerfeld, M. Kummrow, K. Grützmacher, P. Dziallas, P. Wohlsein,