Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2438304 | Journal of Comparative Pathology | 2009 | 6 Pages |
SummaryFeline endometrial adenocarcinomas are uncommon malignant neoplasms that have to date been poorly characterized. The present immunohistochemical study describes the expression of the pancytokeratins AE1 and AE3, cytokeratin-14, vimentin, α-actin, cyclo-oxygenase-2, E-cadherin, β-catenin, the progesterone receptor, the oestrogen receptor and caveolin-1 within normal feline uterine tissue and tissue from six cats with endometrial adenocarcinoma. Synthesis of cyclo-oxygenase-2 and reduced expression of progesterone receptors may be involved in the neoplastic transformation of feline endometrium. The loss of cellular adhesion that occurs within these tumours does not require down-regulation of E-cadherin expression and nuclear translocation of β-catenin is not a feature of these neoplasms.